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DNA REPAIR & GENOME INTEGRITY LAB
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Selected Publications

* Authors contributed equally to this work
​# Corresponding author




Carreira R.*, Aguado F.J.*, Hurtado-Nieves V.,  Blanco M.G. Canonical and novel non-canonical activities of the Holliday junction resolvase Yen1. Nucleic Acids Res. 2022; 50 (1): 259-280.
​DOI: 10.1093/nar/gkab1225. PMCID: 34928393
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Morafraile E.C., Bugallo A., Carreira R., Fernández M., Martín-Castellanos C.,  Blanco M.G., Segurado M. Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins. Nucleic Acids Res. 2020; 48 (6): 3053-3070.
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DOI: 10.1093/nar/gkaa054​. PMCID: PMC7102976
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Arter M., Hurtado-Nieves V.*,  Oke A.*, Zhuge T., Wettstein R., Fung J.C.,  Blanco M.G.#, Matos J.# Regulated crossing-over requires inactivation of Yen1/GEN1 resolvase during meiotic prophase I. Dev. Cell 2018; 45 (6): 785-800.
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DOI: 10.1016/j.devcel.2018.05.020​. PMCID: PMC6043783
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​Guallar D., Bi X., Pardavila J.A., Huang X., Saenz C., Shi X., Zhou H., Faiola F., Ding J., Haruehanroengra P., Yang F., Li D., Sanchez-Priego C., Saunders A., Pan F., Valdes V.J., Kelley K., Blanco M.G., Chen L., Wang H., Sheng J., Xu M., Fidalgo M., Shen X., Wang J. RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells.   Nat. Genet. 2018; 50: 443–451.
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DOI: 10.1038/s41588-018-0060-9​. PMCID: PMC5862756
  
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Princz L.N., Wild P., Bittmann J.,  Aguado F.J.,  Blanco M.G., Matos J., Pfander B.   D. Dbf4-dependent kinase and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosis.   EMBO J. 2017; 36: 664-678. 
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DOI: 10.15252/embj.201694831. PMCID: PMC5331752
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Duda H., Arter M., Gloggnitzer J., Teloni F., Wild P.,  Blanco, M.G., Altmeyer M., Matos, J. A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis.  Dev. Cell 2016; 39: 740-755.
DOI: 10.1016/j.devcel.2016.11.017. PMID: 27997828  

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Blanco M.G.#, Matos J.# Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1. Front. Genet. 2015; 6: 253.
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DOI: 10.3389/fgene.2015.00253 PMID: 26284109​
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Blanco M.G.*, Matos J.*, West S.C. Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability. Mol. Cell. 2014; 54: 94-106. 
DOI: 10.1016/j.molcel.2014.02.011  PMID: 24631285
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Matos J.*, Blanco M.G.*, Maslen S., Skehel J.M. & West S.C. Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis. Cell 2011; 147: 158-72.
DOI: 10.1016/j.cell.2011.08.032 PMID: 21962513 
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Blanco M.G., Matos J., Rass U., Ip S.C.Y. & West S.C. Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae. DNA Repair 2010; 9: 394-402.
DOI: 10.1016/j.dnarep.2009.12.017 PMID: 20106725 
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Ip S.C.*, Rass U.*, Blanco M.G.*, Flynn H.R., Skehel J.M., West S.C. Identification of Holliday junction resolvases from humans and yeast. Nature 2008; 456: 357-61. 
DOI: 10.1038/nature07470 PMID: 19020614 ​ 
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Boán F.* Blanco M.G*., González A., Barros P. and Gómez-Márquez J. Inhibition of DNA synthesis by K+-stabilised G-quadruplex promotes allelic preferential amplification. FEBS Lett. 2004; 571: 112-118.
DOI: 10.1016/j.febslet.2004.06.062 PMID: 15280027​ 
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Blanco M.G.*, Boán F.* and Gómez-Márquez J. A paradox in the in vitro end-joining assays. J. Biol. Chem. 2004; 279: 26797-26801. 
DOI: 10.1074/jbc.M402832200 . PMID: ​15087441
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PUBMED FULL Bibliography
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